Mitochondrial dysfunction: the first domino in brain aging and Alzheimer's disease?

@article{Leuner2007MitochondrialDT,
  title={Mitochondrial dysfunction: the first domino in brain aging and Alzheimer's disease?},
  author={Kristina Leuner and Susanne Hauptmann and Reham Abdel-Kader and Isabel Scherping and U. D. Keil and Johanna B Strosznajder and Anne Eckert and Walter E. M{\"u}ller},
  journal={Antioxidants & redox signaling},
  year={2007},
  volume={9 10},
  pages={1659-75}
}
With the increasing average life span of humans and with decreasing cognitive function in elderly individuals, age-related cognitive disorders including dementia have become a major health problem in society. Aging-related mitochondrial dysfunction underlies many common neurodegenerative disorders diseases, including Alzheimer's disease (AD). AD is characterized by two major histopathological hallmarks, initially intracellular and with the progression of the disease extracellular accumulation… CONTINUE READING

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