Mitochondrial dysfunction, endoplasmic reticulum stress, and apoptosis in Alzheimer's disease.

@article{Takuma2005MitochondrialDE,
  title={Mitochondrial dysfunction, endoplasmic reticulum stress, and apoptosis in Alzheimer's disease.},
  author={Kazuhiro Takuma and Shirley ShiDu Yan and David M. Stern and Kiyofumi Yamada},
  journal={Journal of pharmacological sciences},
  year={2005},
  volume={97 3},
  pages={312-6}
}
Alzheimer's disease (AD) is the most common neurodegenerative disorder of late life characterized by insidious, chronic, and progressive memory impairment in association with the accumulation of senile plaques, neurofibrillary tangles, and massive loss of neurons. Apoptosis is believed to be an important contributor to progression and pathology of neurodegeneration in AD. There is considerable evidence that amyloid beta-peptide, a major component of senile plaques, has the capacity to activate… CONTINUE READING