Mitochondrial dynamics regulating chemoresistance in gynecological cancers.

  title={Mitochondrial dynamics regulating chemoresistance in gynecological cancers.},
  author={Bao Kong and Hideaki Tsuyoshi and Makoto Orisaka and Dar-Bin Shieh and Yoshio Yoshida and Benjamin K-T Tsang},
  journal={Annals of the New York Academy of Sciences},
Chemoresistance enables cancer cells to evade apoptotic stimuli and leads to poor clinical prognosis. It arises from dysregulation of signaling factors responsible for inducing cell proliferation and death and for modulating the microenvironment. In gynecologic cancers, p53 is a pivotal determinant of cisplatin sensitivity, while BCL-2 family members are… CONTINUE READING