Mitochondrial dynamics controls anti-tumour innate immunity by regulating CHIP-IRF1 axis stability

@inproceedings{Gao2017MitochondrialDC,
  title={Mitochondrial dynamics controls anti-tumour innate immunity by regulating CHIP-IRF1 axis stability},
  author={Zhengjun Gao and Yiyuan Li and Fei Wang and Tao Huang and Keqi Fan and Yu Zhang and Jiangyan Zhong and Qian Cao and Tong Chao and Junling Jia and Shuo Yang and Long Zhang and Yichuan Xiao and Ji-yong Zhou and Xin-hua Feng and Jin Jin},
  booktitle={Nature Communications},
  year={2017}
}
Macrophages, dendritic cells and other innate immune cells are involved in inflammation and host defense against infection. Metabolic shifts in mitochondrial dynamics may be involved in Toll-like receptor agonist-mediated inflammatory responses and immune cell polarization. However, whether the mitochondrial morphology in myeloid immune cells affects anti… CONTINUE READING