Mitochondrial dynamics and neuronal fate in Parkinson's disease.

  title={Mitochondrial dynamics and neuronal fate in Parkinson's disease.},
  author={Daniel de Sousa Santos and Sandra M Cardoso},
  volume={12 4},
Along with the impairment of mitochondrial respiration both mitochondrial fission/fusion and mitophagy have been shown to be altered in Parkinson's disease (PD). In both genetic and toxin-induced models of PD an imbalance in mitochondrial morphology is evident, as its correction through modulation of the fission/fusion proteins has been shown to be protective. From the study of the PD-associated genes, namely PINK1 and Parkin, compromised mitochondrial clearance through mitophagy has been… CONTINUE READING

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