Mitochondrial disturbances, excitotoxicity, neuroinflammation and kynurenines: Novel therapeutic strategies for neurodegenerative disorders

@article{Zdori2012MitochondrialDE,
  title={Mitochondrial disturbances, excitotoxicity, neuroinflammation and kynurenines: Novel therapeutic strategies for neurodegenerative disorders},
  author={D{\'e}nes Z{\'a}dori and P{\'e}ter Kliv{\'e}nyi and Levente Szalardy and Ferenc F{\"u}l{\"o}p and J{\'o}zsef Toldi and L{\'a}szl{\'o} V{\'e}csei},
  journal={Journal of the Neurological Sciences},
  year={2012},
  volume={322},
  pages={187-191}
}
A mitochondrial dysfunction causes an abatement in ATP production, the induction of oxidative damage and the propagation of cell death pathways. It is additionally closely related to both glutamate excitotoxicity and neuroinflammation. All of these interconnected aspects of a cellular dysfunction are involved in the pathogenesis of numerous neurological disorders, including those with an acute (e.g. ischemic stroke) or a chronic (e.g. Huntington's disease) onset. Both acute and chronic… Expand
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