Mitochondrial disruption and limited apoptosis of erythroblasts are associated with high risk myelodysplasia. An ultrastructural analysis.

@article{Loosdrecht2001MitochondrialDA,
  title={Mitochondrial disruption and limited apoptosis of erythroblasts are associated with high risk myelodysplasia. An ultrastructural analysis.},
  author={Arjan A. van de Loosdrecht and S J L Brada and Nel R. Blom and Dr. W. D. H. Hendriks and Jan Smit and Else van den Berg and J Th M de Wolf and Edo Vellenga},
  journal={Leukemia research},
  year={2001},
  volume={25 5},
  pages={385-93}
}
AIMS To investigate the ultrastructural characteristics of erythroblasts in myelodysplasia (MDS) which might be of additional importance in understanding its pathogenesis. METHODS AND RESULTS 22 patients were classified according to FAB (French-American-British classification), IPSS (international prognostic score system), cytogenetic risk factors and transfusion dependency. Using electron microscopy, in 77% of the cases, nuclear abnormalities consisting of disrupted membranes and cystic… CONTINUE READING