Mitochondrial diseases.

@article{Nonaka1992MitochondrialD,
  title={Mitochondrial diseases.},
  author={Ikuya Nonaka},
  journal={Current opinion in neurology and neurosurgery},
  year={1992},
  volume={5 5},
  pages={622-32}
}
  • Ikuya Nonaka
  • Published 1992 in Current opinion in neurology and neurosurgery
With the discovery of mitochondrial DNA (mtDNA) mutations in different neuromuscular disorders, investigations now seek to clarify how the mutant mtDNA induces biochemical and morphologic defects. In one of the most important approaches human mutant mtDNA is transferred into cells that lack mtDNA to examine the relationship between the amount of mutant mtDNA and defects in cell growth, respiration and enzyme activities. The resulting cells are 'cybrids'; these clonal cells contain the… CONTINUE READING

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