Mitochondrial diseases in man and mouse.

@article{Wallace1999MitochondrialDI,
  title={Mitochondrial diseases in man and mouse.},
  author={Douglas C. Wallace},
  journal={Science},
  year={1999},
  volume={283 5407},
  pages={
          1482-8
        }
}
Over the past 10 years, mitochondrial defects have been implicated in a wide variety of degenerative diseases, aging, and cancer. Studies on patients with these diseases have revealed much about the complexities of mitochondrial genetics, which involves an interplay between mutations in the mitochondrial and nuclear genomes. However, the pathophysiology of mitochondrial diseases has remained perplexing. The essential role of mitochondrial oxidative phosphorylation in cellular energy production… CONTINUE READING

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