Mitochondrial degeneration in dystrophic neurites of senile plaques may lead to extracellular deposition of fine filaments

@article{Fiala2007MitochondrialDI,
  title={Mitochondrial degeneration in dystrophic neurites of senile plaques may lead to extracellular deposition of fine filaments},
  author={John C. Fiala and Marcia D Feinberg and Alan Peters and Helen Barbas},
  journal={Brain Structure and Function},
  year={2007},
  volume={212},
  pages={195-207}
}
Recent data show that amyloid precursor protein accumulates inside axons after disruption of fast axonal transport, but how this leads to mature plaques with extracellular amyloid remains unclear. To investigate this issue, primitive plaques in prefrontal cortex of aged rhesus monkeys were reconstructed using serial section electron microscopy. The swollen profiles of dystrophic neurites were found to be diverticula from the main axis of otherwise normal neurites. Microtubules extended from the… CONTINUE READING

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