Mitochondrial defects in cardiomyopathy and neuromuscular disease.

  title={Mitochondrial defects in cardiomyopathy and neuromuscular disease.},
  author={Douglas C. Wallace},
  journal={American heart journal},
  volume={139 2 Pt 3},
Over the past 11 years, a considerable body of evidence has accumulated implicating defects in the mitochondrial energy-generating pathway, oxidative phosphorylation, in a wide variety of degenerative diseases including myopathy and cardiomyopathy. Most classes of pathogenic mitochondrial DNA mutations affect the heart, in association with a variety of other clinical manifestations that can include skeletal muscle, the central nervous system (including eye), the endocrine system, and the renal… CONTINUE READING


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