Mitochondrial cyclophilin D regulates T cell metabolic responses and disease tolerance to tuberculosis

@article{Tzelepis2018MitochondrialCD,
  title={Mitochondrial cyclophilin D regulates T cell metabolic responses and disease tolerance to tuberculosis},
  author={Fanny Tzelepis and Julianna Blagih and Nargis Khan and Joshua Gillard and Laura E Mendonça and Dominic Guy Roy and Eric H. Ma and Philippe Joubert and Russell G. Jones and Maziar Divangahi},
  journal={Science Immunology},
  year={2018},
  volume={3}
}
Mycobacterium tuberculosis (Mtb) is one of the most ancient human pathogens, yet the exact mechanism(s) of host defense against Mtb remains unclear. Although one-third of the world’s population is chronically infected with Mtb, only 5 to 10% develop active disease. This indicates that, in addition to resistance mechanisms that control bacterial burden, the… CONTINUE READING