Mitochondrial coupling and capacity of oxidative phosphorylation in skeletal muscle of Inuit and Caucasians in the arctic winter.

@article{Gnaiger2015MitochondrialCA,
  title={Mitochondrial coupling and capacity of oxidative phosphorylation in skeletal muscle of Inuit and Caucasians in the arctic winter.},
  author={Erich Gnaiger and R Boushel and Hans S\ondergaard and Thor Munch-Andersen and Rasmus Damsgaard and CornelisW. Hagen and Carmen D{\'i}ez-S{\'a}nchez and Ignacio Ara and Cynthia Wright-Paradis and Patrick Schrauwen and Matthijs K. C. Hesselink and Jos{\'e} A L Calbet and Michael Christiansen and J\orn Wulff Helge and Bengt Saltin},
  journal={Scandinavian journal of medicine & science in sports},
  year={2015},
  volume={25 Suppl 4},
  pages={126-34}
}
During evolution, mitochondrial DNA haplogroups of arctic populations may have been selected for lower coupling of mitochondrial respiration to ATP production in favor of higher heat production. We show that mitochondrial coupling in skeletal muscle of traditional and westernized Inuit habituating northern Greenland is identical to Danes of western Europe haplogroups. Biochemical coupling efficiency was preserved across variations in diet, muscle fiber type, and uncoupling protein-3 content… CONTINUE READING
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