Mitochondrial contact sites: their role in energy metabolism and apoptosis.

  title={Mitochondrial contact sites: their role in energy metabolism and apoptosis.},
  author={Dieter G Brdiczka and Dmitry B. Zorov and Shey-Shing Sheu},
  journal={Biochimica et biophysica acta},
  volume={1762 2},
The energy metabolism of the failing heart is characterised by a 30% decrease of the total adenine nucleotides content and what may be more important by a 60% loss of creatine and creatine phosphate [J.S. Ingwall, R.G. Weiss, Is the failing heart energy starved? On using chemical energy to support cardiac function, Circ. Res. 95 (2004) 35-145]. Besides the effect of these changes on the energy supply, failing heart is known to be more vulnerable to Ca2+ overload and apoptosis-inducing processes… CONTINUE READING
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