Mitochondrial consumption of cytosolic ATP: Not so fast

@article{Chinopoulos2011MitochondrialCO,
  title={Mitochondrial consumption of cytosolic ATP: Not so fast},
  author={C. Chinopoulos},
  journal={FEBS Letters},
  year={2011},
  volume={585}
}
In various pathologic circumstances depolarized mitochondria are thought to precipitate cell death by avidly consuming cytosolic ATP. However, for as long as the inner mitochondrial membrane remains intact the reversal potentials of the adenine nucleotide translocase (ANT) and that of F0–F1 ATP synthase are strategically positioned so that they oppose import of cytosolic ATP into the matrix of respiration‐impaired mitochondria. This arrangement also seems to protect against a hysteretic… Expand
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