Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing.

@article{Guzy2005MitochondrialCI,
  title={Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing.},
  author={Robert D Guzy and Beatrice E. Hoyos and Emmanuel Robin and Hong Chen and Liping Liu and Kyle D Mansfield and M Celeste Simon and Ulrich Hammerling and Paul T Schumacker},
  journal={Cell metabolism},
  year={2005},
  volume={1 6},
  pages={401-8}
}
Multicellular organisms initiate adaptive responses when oxygen (O(2)) availability decreases, but the underlying mechanism of O(2) sensing remains elusive. We find that functionality of complex III of the mitochondrial electron transport chain (ETC) is required for the hypoxic stabilization of HIF-1 alpha and HIF-2 alpha and that an increase in reactive oxygen species (ROS) links this complex to HIF-alpha stabilization. Using RNAi to suppress expression of the Rieske iron-sulfur protein of… CONTINUE READING
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