Mitochondrial complex I.

@article{Hirst2013MitochondrialCI,
  title={Mitochondrial complex I.},
  author={Judy Hirst},
  journal={Annual review of biochemistry},
  year={2013},
  volume={82},
  pages={
          551-75
        }
}
Complex I (NADH:ubiquinone oxidoreductase) is crucial for respiration in many aerobic organisms. In mitochondria, it oxidizes NADH from the tricarboxylic acid cycle and β-oxidation, reduces ubiquinone, and transports protons across the inner membrane, contributing to the proton-motive force. It is also a major contributor to cellular production of reactive oxygen species. The redox reaction of complex I is catalyzed in the hydrophilic domain; it comprises NADH oxidation by a flavin… CONTINUE READING

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