Mitochondrial complex I inhibition in Parkinson's disease: how can curcumin protect mitochondria?

@article{Mythri2007MitochondrialCI,
  title={Mitochondrial complex I inhibition in Parkinson's disease: how can curcumin protect mitochondria?},
  author={Rajeswara Babu Mythri and Balusamy Jagatha and Nityananda Pradhan and Julie S Andersen and Muchukunte Mukunda Srinivas Bharath},
  journal={Antioxidants & redox signaling},
  year={2007},
  volume={9 3},
  pages={399-408}
}
Selective damage of mitochondrial complex I within the dopaminergic neurons of the substantia nigra is the central event during Parkinson disease. Peroxynitrite is one of the important free radicals probably mediating complex I damage. Peroxynitrite inhibits brain complex I mainly by 3-nitrotyrosine and nitrosothiol formation, but how these modifications alter the structure-function relation of complex I is unclear. Curcumin pretreatment protects brain mitochondria against peroxynitrite in… CONTINUE READING
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