Mitochondrial complex I deficiency and ATP/ADP ratio in lymphocytes of amyotrophic lateral sclerosis patients.

@article{Ghiasi2012MitochondrialCI,
  title={Mitochondrial complex I deficiency and ATP/ADP ratio in lymphocytes of amyotrophic lateral sclerosis patients.},
  author={Parisa Ghiasi and Saman Hosseinkhani and Alireza Noori and Shahriar Nafissi and Khosro Khajeh},
  journal={Neurological research},
  year={2012},
  volume={34 3},
  pages={297-303}
}
OBJECTIVES Several lines of evidence suggest that mitochondrial dysfunction is involved in amyotrophic lateral sclerosis (ALS), but despite the fact that mitochondria play a central role in excitotoxicity, oxidative stress, and apoptosis, the intimate underlying mechanism linking mitochondrial defects to motor neuron degeneration in ALS still remains elusive. This study was performed to assess the mitochondrial respiratory chain dysfunction and cellular energy index (ATP/ADP ratio) in… CONTINUE READING
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Complex I deficiency and ATP/ADP ratio in lymphocytes of ALS

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  • Neurological Research 2012 VOL
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2 Excerpts

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