Mitochondrial common deletion is elevated in blood of breast cancer patients mediated by oxidative stress.

@article{Nie2016MitochondrialCD,
  title={Mitochondrial common deletion is elevated in blood of breast cancer patients mediated by oxidative stress.},
  author={Hezhongrong Nie and Guorong Chen and Jing He and Fengjiao Zhang and Ming Li and Qiufeng Wang and Huaibin Zhou and Jianxin Lyu and Yidong Bai},
  journal={Mitochondrion},
  year={2016},
  volume={26},
  pages={
          104-12
        }
}
The 4977 bp common deletion is one of the most frequently observed mitochondrial DNA (mtDNA) mutations in human tissues and has been implicated in various human cancer types. It is generally believed that continuous generation of intracellular reactive oxygen species (ROS) during oxidative phosphorylation (OXPHOS) is a major underlying mechanism for generation of such mtDNA deletions while antioxidant systems, including Manganese superoxide dismutase (MnSOD), mitigating the deleterious effects… CONTINUE READING
BETA

Citations

Publications citing this paper.

Similar Papers