Mitochondrial changes associated with glutathione deficiency.

  title={Mitochondrial changes associated with glutathione deficiency.},
  author={Alton Meister},
  journal={Biochimica et biophysica acta},
  volume={1271 1},
Glutathione deficiency produced by giving buthionine sulfoximine (an inhibitor of gamma-glutamylcysteine synthetase) to animals, leads to biphasic decline in cellular glutathione levels associated with sequestration of glutathione in mitochondria. Liver mitochondria lack the enzymes needed for glutathione synthesis. Mitochondrial glutathione arises from the cytosol. Rat liver mitochondria have a multicomponent system (with Kms of approx. 60 microM and 5.4 mM) that underlies their remarkable… CONTINUE READING


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