Mitochondrial carriers in inflammation induced by bacterial endotoxin and cytokines.

@article{Iacobazzi2016MitochondrialCI,
  title={Mitochondrial carriers in inflammation induced by bacterial endotoxin and cytokines.},
  author={Vito Iacobazzi and Vittoria Infantino and Alessandra Castegna and Alessio Menga and Erika Mariana Palmieri and Paolo Convertini and Ferdinando Palmieri},
  journal={Biological chemistry},
  year={2016},
  volume={398 3},
  pages={
          303-317
        }
}
Significant metabolic changes occur in the shift from resting to activated cellular status in inflammation. Thus, changes in expression of a large number of genes and extensive metabolic reprogramming gives rise to acquisition of new functions (e.g. production of cytokines, intermediates for biosynthesis, lipid mediators, PGE, ROS and NO). In this context, mitochondrial carriers, which catalyse the transport of solute across mitochondrial membrane, change their expression to transport… CONTINUE READING

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