Mitochondrial capacity in skeletal muscle is not stimulated by weight loss despite increases in insulin action and decreases in intramyocellular lipid content.

@article{Toledo2008MitochondrialCI,
  title={Mitochondrial capacity in skeletal muscle is not stimulated by weight loss despite increases in insulin action and decreases in intramyocellular lipid content.},
  author={Frederico G. S. Toledo and Elizabeth V. Menshikova and Koichiro Azuma and Žofia R{\'a}dikov{\'a} and Carol A Kelley and Vladimir B. Ritov and David E Kelley},
  journal={Diabetes},
  year={2008},
  volume={57 4},
  pages={987-94}
}
OBJECTIVE In obesity and type 2 diabetes, exercise combined with weight loss increases skeletal muscle mitochondrial capacity. It remains unclear whether mitochondrial capacity increases because of weight loss, improvements in insulin resistance, or physical training. In this study, we examined the effects of an intervention of weight loss induced by diet and compared these with those of a similar intervention of weight loss by diet with exercise. Both are known to improve insulin resistance… CONTINUE READING
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