Mitochondrial calcium spiking: a transduction mechanism based on calcium-induced permeability transition involved in cell calcium signalling.

@article{Ichas1994MitochondrialCS,
  title={Mitochondrial calcium spiking: a transduction mechanism based on calcium-induced permeability transition involved in cell calcium signalling.},
  author={François Ichas and Laurence Sophie Jouaville and S S Sidash and J. P. Mazat and Ekhson L. Holmuhamedov},
  journal={FEBS letters},
  year={1994},
  volume={348 2},
  pages={211-5}
}
We report reversible Ca(2+)-induced Ca2+ release from mitochondria, which takes the form of Ca2+ spikes. Mitochondrial Ca2+ spiking is an all-or-none process with a threshold dependence on both the frequency and the amplitude of the Ca2+ pulses used as stimuli. This spiking relies on the transient operation of the mitochondrial permeability transition pore, and is initiated--in a threshold-dependent manner--with inositol-triphosphate-mediated Ca2+ responses on permeabilized cells. Evidence that… CONTINUE READING

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