Mitochondrial calcium oscillations in C2C12 myotubes.

@article{Challet2001MitochondrialCO,
  title={Mitochondrial calcium oscillations in C2C12 myotubes.},
  author={Corinne Challet and Pierre Maechler and Claes B Wollheim and Urs T. Ruegg},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 6},
  pages={3791-7}
}
Mitochondrial Ca(2+) concentration ([Ca(2+)](m)) was monitored in C2C12 skeletal muscle cells stably expressing the Ca(2+)-sensitive photoprotein aequorin targeted to mitochondria. In myotubes, KCl-induced depolarization caused a peak of 3.03 +/- 0.14 micrometer [Ca(2+)](m) followed by an oscillatory second phase (5.1 +/- 0.1 per min). Chelation of extracellular Ca(2+) or blockade of the voltage-operated Ca(2+) channel attenuated both phases of the KCl response. The inhibitor of the… CONTINUE READING
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Mitochondrial Calcium Oscillations in C2C12 Myotubes 3797 by gest on N ovem er 7, 2016 hp://w w w .jb.org/ D

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