Mitochondrial calcium and the permeability transition in cell death.

@article{Lemasters2009MitochondrialCA,
  title={Mitochondrial calcium and the permeability transition in cell death.},
  author={John J. Lemasters and Tom P. Theruvath and Zhi Zhong and Anna Liisa Nieminenll},
  journal={Biochimica et biophysica acta},
  year={2009},
  volume={1787 11},
  pages={
          1395-401
        }
}
Dysregulation of Ca(2+) has long been implicated to be important in cell injury. A Ca(2+)-linked process important in necrosis and apoptosis (or necrapoptosis) is the mitochondrial permeability transition (MPT). In the MPT, large conductance permeability transition (PT) pores open that make the mitochondrial inner membrane abruptly permeable to solutes up to 1500 Da. The importance of Ca(2+) in MPT induction varies with circumstance. Ca(2+) overload is sufficient to induce the MPT. By contrast… CONTINUE READING
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