Mitochondrial biogenesis through activation of nuclear signaling proteins.

@article{Dominy2013MitochondrialBT,
  title={Mitochondrial biogenesis through activation of nuclear signaling proteins.},
  author={John E. Dominy and Pere B. Puigserver},
  journal={Cold Spring Harbor perspectives in biology},
  year={2013},
  volume={5 7}
}
The dynamics of mitochondrial biogenesis and function is a complex interplay of cellular and molecular processes that ultimately shape bioenergetics capacity. Mitochondrial mass, by itself, represents the net balance between rates of biogenesis and degradation. Mitochondrial biogenesis is dependent on different signaling cascades and transcriptional complexes that promote the formation and assembly of mitochondria--a process that is heavily dependent on timely and coordinated transcriptional… CONTINUE READING
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