Mitochondrial biogenesis and neural differentiation of human iPSC is modulated by idebenone in a developmental stage-dependent manner

@inproceedings{Augustyniak2017MitochondrialBA,
  title={Mitochondrial biogenesis and neural differentiation of human iPSC is modulated by idebenone in a developmental stage-dependent manner},
  author={Justyna Augustyniak and Jacek Lenart and Marzena Zychowicz and Piotr P Stepien and Leonora Buzanska},
  booktitle={Biogerontology},
  year={2017}
}
Idebenone, the synthetic analog of coenzyme Q10 can improve electron transport in mitochondria. Therefore, it is used in the treatment of Alzheimer’s disease and other cognitive impairments. However, the mechanism of its action on neurodevelopment is still to be elucidated. Here we demonstrate that the cellular response of human induced pluripotent stem cells (hiPSC) to idebenone depends on the stage of neural differentiation. When: neural stem cells (NSC), early neural progenitors (eNP) and… CONTINUE READING
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