Mitochondrial biogenesis and fission in axons in cell culture and animal models of diabetic neuropathy

@article{Vincent2010MitochondrialBA,
  title={Mitochondrial biogenesis and fission in axons in cell culture and animal models of diabetic neuropathy},
  author={Andrea M. Vincent and James L. Edwards and Lisa L. McLean and Yu Xuan Hong and Federica Cerri and Ignazio Lopez and Angelo Quattrini and Eva L. Feldman},
  journal={Acta Neuropathologica},
  year={2010},
  volume={120},
  pages={477-489}
}
Mitochondrial-mediated oxidative stress in response to high glucose is proposed as a primary cause of dorsal root ganglia (DRG) neuron injury in the pathogenesis of diabetic neuropathy. In the present study, we report a greater number of mitochondria in both myelinated and unmyelinated dorsal root axons in a well-established model of murine diabetic neuropathy. No similar changes were seen in younger diabetic animals without neuropathy or in the ventral motor roots of any diabetic animals… CONTINUE READING