Mitochondrial bioenergetics and dynamics in Huntington's disease: tripartite synapses and selective striatal degeneration.

  • Jorge Oliveira
  • Published 2010 in Journal of bioenergetics and biomembranes

Abstract

Preferential striatal neurodegeneration is a hallmark of Huntington's disease (HD) pathogenesis, which has been associated with mitochondrial dysfunction. Evidence from genetic HD models suggest that mutant huntingtin (mHtt) compromises mitochondrial bioenergetics and dynamics, preventing efficient calcium handling and ATP generation in neuronal networks… (More)
DOI: 10.1007/s10863-010-9287-6

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Cite this paper

@article{Oliveira2010MitochondrialBA, title={Mitochondrial bioenergetics and dynamics in Huntington's disease: tripartite synapses and selective striatal degeneration.}, author={Jorge Oliveira}, journal={Journal of bioenergetics and biomembranes}, year={2010}, volume={42 3}, pages={227-34} }