Mitochondrial beta-oxidation in Aspergillus nidulans.

  title={Mitochondrial beta-oxidation in Aspergillus nidulans.},
  author={Lori A Maggio-Hall and Nancy P Keller},
  journal={Molecular microbiology},
  volume={54 5},
Beta-oxidation (beta-ox) occurs exclusively in the peroxisomes of Saccharomyces cerevisiae and other yeasts, leading to the supposition that fungi lack mitochondrial beta-ox. Here we present unequivocal evidence that the filamentous fungus Aspergillus nidulans houses both peroxisomal and mitochondrial beta-ox. While growth of a peroxisomal beta-ox disruption mutant (DeltafoxA) was eliminated on a very long-chain fatty acid (C(22:1)), growth was only partially impeded on a long-chain fatty acid… CONTINUE READING

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