Mitochondrial benzodiazepine receptors regulate steroid biosynthesis.

  title={Mitochondrial benzodiazepine receptors regulate steroid biosynthesis.},
  author={Alexey G. Mukhin and Vassilios Papadopoulos and Erminio Costa and Karl E. Krueger},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={86 24},
Recent observations on the steroid synthetic capability within the brain open the possibility that benzodiazepines may influence steroid synthesis in nervous tissue through interactions with peripheral-type benzodiazepine recognition sites, which are highly expressed in steroidogenic cells and associated with the outer mitochondrial membrane. To examine this possibility nine molecules that exhibit a greater than 10,000-fold difference in their affinities for peripheral-type benzodiazepine… CONTINUE READING


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