Mitochondrial-associated endoplasmic reticulum membranes (MAM) form innate immune synapses and are targeted by hepatitis C virus.

@article{Horner2011MitochondrialassociatedER,
  title={Mitochondrial-associated endoplasmic reticulum membranes (MAM) form innate immune synapses and are targeted by hepatitis C virus.},
  author={Stacy M Horner and Helene Minyi Liu and Hae Soo Park and Jessica Briley and Michael Gale},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 35},
  pages={14590-5}
}
RIG-I is a cytosolic pathogen recognition receptor that engages viral RNA in infected cells to trigger innate immune defenses through its adaptor protein MAVS. MAVS resides on mitochondria and peroxisomes, but how its signaling is coordinated among these organelles has not been defined. Here we show that a major site of MAVS signaling is the mitochondrial-associated membrane (MAM), a distinct membrane compartment that links the endoplasmic reticulum to mitochondria. During RNA virus infection… CONTINUE READING
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