Mitochondrial aspartate aminotransferase: a third kynurenate‐producing enzyme in the mammalian brain

  title={Mitochondrial aspartate aminotransferase: a third kynurenate‐producing enzyme in the mammalian brain},
  author={P. Guidetti and L. Amori and M. T. Sapko and E. Okuno and R. Schwarcz},
  journal={Journal of Neurochemistry},
  • P. Guidetti, L. Amori, +2 authors R. Schwarcz
  • Published 2007
  • Biology, Medicine
  • Journal of Neurochemistry
  • The tryptophan metabolite kynurenic acid (KYNA), which is produced enzymatically by the irreversible transamination of l‐kynurenine, is an antagonist of α7 nicotinic and NMDA receptors and may thus modulate cholinergic and glutamatergic neurotransmission. Two kynurenine aminotransferases (KAT I and II) are currently considered the major biosynthetic enzymes of KYNA in the brain. In this study, we report the existence of a third enzyme displaying KAT activity in the mammalian brain. The novel… CONTINUE READING
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