• DOI:10.1111/j.1471-4159.2007.04556.x
Corpus ID: 20413002

Mitochondrial aspartate aminotransferase: a third kynurenate‐producing enzyme in the mammalian brain

@article{Guidetti2007MitochondrialAA,
  title={Mitochondrial aspartate aminotransferase: a third kynurenate‐producing enzyme in the mammalian brain},
  author={P. Guidetti and L. Amori and M. T. Sapko and E. Okuno and R. Schwarcz},
  journal={Journal of Neurochemistry},
  year={2007},
  volume={102}
}

P. Guidetti, L. Amori, +2 authors R. Schwarcz

Published 2007

Biology, Medicine

Journal of Neurochemistry

The tryptophan metabolite kynurenic acid (KYNA), which is produced enzymatically by the irreversible transamination of l‐kynurenine, is an antagonist of α7 nicotinic and NMDA receptors and may thus modulate cholinergic and glutamatergic neurotransmission. Two kynurenine aminotransferases (KAT I and II) are currently considered the major biosynthetic enzymes of KYNA in the brain. In this study, we report the existence of a third enzyme displaying KAT activity in the mammalian brain. The novel… CONTINUE READING

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