Mitochondrial anomalies in renal oncocytes induced in rat by N-nitrosomorpholine.

  title={Mitochondrial anomalies in renal oncocytes induced in rat by N-nitrosomorpholine.},
  author={Rainer Horst Krech and Heide Zerban and Peter Bannasch},
  journal={European journal of cell biology},
  volume={25 2},
Renal oncocytes were induced in male Sprague-Dawley rats by oral application of N-nitrosomorpholine (NNM) in a concentration of 12 or 50 mg per 100 ml drinking water and analysed by transmission electron microscopy. The oncocytes exhibited mitochondrial anomalies which were very similar to those of human oncocytoma oncocytes. The most striking mitochondrial changes were an unusually large number of the organelles and an excess of the cristae mitochondriales. The shape of the mitochondria varied… CONTINUE READING


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