Mitochondrial and nuclear DNA base excision repair are affected differently by caloric restriction

@article{Stuart2004MitochondrialAN,
  title={Mitochondrial and nuclear DNA base excision repair are affected differently by caloric restriction},
  author={Jeff A. Stuart and Bensu Karahalil and Barbara A. Hogue and N C Souza-Pinto and Vilhelm A. Bohr},
  journal={The FASEB Journal},
  year={2004},
  volume={18}
}
Aging is strongly correlated with the accumulation of oxidative damage in DNA, particularly in mitochondria. Oxidative damage to both mitochondrial and nuclear DNA is repaired by the base excision repair (BER) pathway. The “mitochondrial theory of aging” suggests that aging results from declining mitochondrial function, due to high loads of damage and mutation in mitochondrial DNA (mtDNA). Restriction of caloric intake is the only intervention so far proven to slow the aging rate. However, the… 

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TLDR
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The results agree with the idea that CR decreases aging rate in part by lowering the rate of free radical generation of mitochondria in the brain.

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