Mitochondrial and intracellular free-calcium regulation of radiation-induced apoptosis in human leukemic cells.

@article{Zhao1999MitochondrialAI,
  title={Mitochondrial and intracellular free-calcium regulation of radiation-induced apoptosis in human leukemic cells.},
  author={Qingwei Zhao and Takeshi Kondo and Asao Noda and Yoko Fujiwara},
  journal={International journal of radiation biology},
  year={1999},
  volume={75 4},
  pages={493-504}
}
PURPOSE To investigate the mechanisms and pathways of X-ray apoptosis in Molt-4 cells, focusing on mitochondrial and cytosolic Ca2+ ([Ca2+]i) regulation. MATERIALS AND METHODS X-irradiated Molt-4 cells and cell extract (CE) were used to analyse: (1) induced apoptosis (Giemsa stain), (2) p53, Bcl-2 and Bax expressions (immunoblot), (3) mitochondrial… CONTINUE READING