Mitochondrial and cytoplasmic thioredoxin reductase variants encoded by a single Drosophila gene are both essential for viability.

@article{Missirlis2002MitochondrialAC,
  title={Mitochondrial and cytoplasmic thioredoxin reductase variants encoded by a single Drosophila gene are both essential for viability.},
  author={Fanis Missirlis and Julia K Ulschmid and Mitsuko Hirosawa-Takamori and Sebastian Gr{\"o}nke and Ulrich Sch{\"a}fer and Katja Becker and J. P. Phillips and Herbert Jaeckle},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 13},
  pages={11521-6}
}
Defense against oxidative stress in mammals includes the regeneration of the major thiol reductants glutathione and thioredoxin by glutathione reductase and thioredoxin reductase (TrxR), respectively. In contrast, Drosophila, and possibly insects in general, lacks glutathione reductase and must rely solely on the TrxR system. The mammalian TrxRs described so far are selenoproteins that utilize NADPH to reduce protein as well as nonprotein substrates in mitochondria and cytoplasm of cells. We… CONTINUE READING
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