Mitochondrial and apoptotic neuronal death signaling pathways in cerebral ischemia.

  title={Mitochondrial and apoptotic neuronal death signaling pathways in cerebral ischemia.},
  author={Kuniyasu Niizuma and Hideyuki Yoshioka and Hai Chen and Gab Seok Kim and Joo Eun Jung and Masataka Katsu and Nobuya Okami and Pak Hoo Chan},
  journal={Biochimica et biophysica acta},
  volume={1802 1},
Mitochondria play important roles as the powerhouse of the cell. After cerebral ischemia, mitochondria overproduce reactive oxygen species (ROS), which have been thoroughly studied with the use of superoxide dismutase transgenic or knockout animals. ROS directly damage lipids, proteins, and nucleic acids in the cell. Moreover, ROS activate various molecular signaling pathways. Apoptosis-related signals return to mitochondria, then mitochondria induce cell death through the release of pro… CONTINUE READING
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