Mitochondrial alterations, oxidative stress and neuroinflammation in Alzheimer's disease.

  title={Mitochondrial alterations, oxidative stress and neuroinflammation in Alzheimer's disease.},
  author={Manuela Verri and Ornella Pastoris and Marta Dossena and Roberto Aquilani and Fabio Guerriero and Gianni Cuzzoni and Letizia Venturini and Giovanni Ricevuti and Andria Innocenza Bongiorno},
  journal={International journal of immunopathology and pharmacology},
  volume={25 2},
Alzheimer's disease (AD) is a multifactorial disorder characterized by the progressive deterioration of neuronal networks. The primary cause and sequence of its progression are only partially understood but abnormalities in folding and accumulation of insoluble proteins such as beta-amyloid and Tau-protein are both associated with the pathogenesis of AD. Mitochondria play a crucial role in cell survival and death, and changes in mitochondrial structure and/or function are related to many human… CONTINUE READING
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