Mitochondrial alterations, cellular response to oxidative stress and defective degradation of proteins in aging

@article{Lee2001MitochondrialAC,
  title={Mitochondrial alterations, cellular response to oxidative stress and defective degradation of proteins in aging},
  author={Hsin-Chen Lee and Yau-Huei Wei},
  journal={Biogerontology},
  year={2001},
  volume={2},
  pages={231-244}
}
Respiratory function decline and increase ofoxidative stress in mitochondria have beenproposed as important contributors to humanaging. A wide spectrum of alterations in agedindividuals and senescent cells are similar andare correlated to cellular response tosublethal dose of oxidative stress. Thesealterations and responses include: (1) declinein mitochondrial respiratory function; (2)increase in the rate of production of reactiveoxygen species (ROS); (3) accumulation ofmitochondrial DNA (mtDNA… CONTINUE READING