Mitochondrial aldehyde dehydrogenase-2 deficiency compromises therapeutic effect of ALDH bright cell on peripheral ischemia

@inproceedings{Sun2017MitochondrialAD,
  title={Mitochondrial aldehyde dehydrogenase-2 deficiency compromises therapeutic effect of ALDH bright cell on peripheral ischemia},
  author={Xiaolei Sun and Hong Zhu and Zhen Dong and Xiangwei Liu and Xin Ma and Shasha Han and Fei Lu and Peng Wang and Sanli Qian and Cong Wang and Cheng Che Shen and Xiaona Zhao and Yun-zeng Zou and Junbo Ge and Aijun Sun},
  booktitle={Redox biology},
  year={2017}
}
The autologous ALDH bright (ALDHbr) cell therapy for ischemic injury is clinically safe and effective, while the underlying mechanism remains elusive. Here, we demonstrated that the glycolysis dominant metabolism of ALDHbr cells is permissive to restore blood flow in an ischemic hind limb model compared with bone marrow mononuclear cells (BMNCs). PCR array… CONTINUE READING