Mitochondrial adaptations and dysfunctions in nonalcoholic fatty liver disease.

Abstract

The worldwide epidemic of obesity and insulin resistance favors nonalcoholic fatty liver disease (NAFLD). Insulin resistance (IR) in the adipose tissue increases lipolysis and the entry of nonesterified fatty acids (NEFAs) in the liver, whereas IR-associated hyperinsulinemia promotes hepatic de novo lipogenesis. However, several hormonal and metabolic… (More)
DOI: 10.1002/hep.26226

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