Mitochondrial acetylome analysis in a mouse model of alcohol-induced liver injury utilizing SIRT3 knockout mice.

@article{Fritz2012MitochondrialAA,
  title={Mitochondrial acetylome analysis in a mouse model of alcohol-induced liver injury utilizing SIRT3 knockout mice.},
  author={Kristofer S Fritz and James J Galligan and Matthew D Hirschey and Eric Verdin and Dennis R. Petersen},
  journal={Journal of proteome research},
  year={2012},
  volume={11 3},
  pages={1633-43}
}
Mitochondrial protein hyperacetylation is a known consequence of sustained ethanol consumption and has been proposed to play a role in the pathogenesis of alcoholic liver disease (ALD). The mechanisms underlying this altered acetylome, however, remain unknown. The mitochondrial deacetylase sirtuin 3 (SIRT3) is reported to be the major regulator of mitochondrial protein deacetylation and remains a central focus for studies on protein acetylation. To investigate the mechanisms underlying ethanol… CONTINUE READING

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