Mitochondrial accumulation of polyubiquitinated proteins and differential regulation of apoptosis by polyubiquitination sites Lys‐48 and ‐63

@inproceedings{Sun2009MitochondrialAO,
  title={Mitochondrial accumulation of polyubiquitinated proteins and differential regulation of apoptosis by polyubiquitination sites Lys‐48 and ‐63},
  author={Faneng Sun and Arthi Kanthasamy and Vellareddy Anantharam and Anumantha G Kanthasamy},
  booktitle={Journal of cellular and molecular medicine},
  year={2009}
}
Proteins tagged with lysine (Lys, K) 48 polyubiquitins chains are destined for degradation by the 26S proteasomal system. Impairment of the ubiquitin proteasome system (UPS) function culminates in the accumulation of polyubiquitinated proteins in many neurodegenerative conditions including Parkinson's disease (PD). Nevertheless, the cellular mechanisms underlying cell death induced by an impaired UPS are still not clear. Intriguingly, recent studies indicate that several proteins associated… CONTINUE READING
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Ubiquitin-proteasomedependent degradation of a mitofusin, a critical regulator of mitochondrial fusion

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