Mitochondrial abnormalities in tumor necrosis factor-alpha-induced heart failure are associated with impaired DNA repair activity.

@article{Li2001MitochondrialAI,
  title={Mitochondrial abnormalities in tumor necrosis factor-alpha-induced heart failure are associated with impaired DNA repair activity.},
  author={Yun You Li and Daxin Chen and Simon C. Watkins and Arthur M Feldman},
  journal={Circulation},
  year={2001},
  volume={104 20},
  pages={2492-7}
}
BACKGROUND Recent studies suggest that mutations in cardiac mitochondrial DNA (mtDNA) may contribute to the development of dilated cardiomyopathy. The mechanisms that regulate those mutations, however, remain undefined. Thus, we studied cardiac mtDNA repair mechanisms, mtDNA damage, and mitochondrial structure and function in mice with heart failure secondary to overexpression of TNF-alpha (TNF1.6 mice). METHODS AND RESULTS We studied mtDNA repair by measuring the uracil DNA glycosylase… CONTINUE READING

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