Mitochondrial abnormalities in non-alcoholic steatohepatitis.

  title={Mitochondrial abnormalities in non-alcoholic steatohepatitis.},
  author={Stephen Hugh Caldwell and Russell Howard Swerdlow and Ejaz Muhammad Khan and Julia C. Iezzoni and Elizabeth Erickson Hespenheide and Janice K Parks and Wayne D. Parker},
  journal={Journal of hepatology},
  volume={31 3},
BACKGROUND/AIMS We assessed mitochondrial morphology by electron microscopy and the prevalence of a mitochondrial gene deletion in patients with non-alcoholic steatohepatitis (NASH), alcohol-related liver disease and non-fatty liver diseases. Respiratory chain function using a cytoplasmic hybrid (cybrid) assay was further studied in NASH patients and healthy controls. METHODS Electron microscopy was performed in 26 specimens. Fifteen patients were studied by polymerase chain reaction to… CONTINUE READING


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