Mitochondrial abnormalities in myocardium of dogs with chronic heart failure.

  title={Mitochondrial abnormalities in myocardium of dogs with chronic heart failure.},
  author={Hani N. Sabbah and Victor G. Sharov and Jeanne M. Riddle and Tatsuji Kono and Michael Lesch and Sidney Goldstein},
  journal={Journal of molecular and cellular cardiology},
  volume={24 11},
The number, size and structural integrity of mitochondria (MIT) were evaluated in the myocardium of 12 dogs with chronic heart failure (CHF) produced by sequential intracoronary microembolizations (EMB). Tissue specimens for transmission electron microscopy were obtained from the left ventricular (LV) free wall, septum and right ventricular free wall 3 to 4 months after the last EMB. Comparisons were made with samples obtained from identical sites in 9 control dogs. In dogs with CHF, LV… CONTINUE READING


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