Mitochondrial abnormalities in ageing macular photoreceptors.

  title={Mitochondrial abnormalities in ageing macular photoreceptors.},
  author={Martin J. Barron and Margaret A T Johnson and Richard M. Andrews and Michael Patrick Clarke and Philip G. Griffiths and Erin N Bristow and L P He and Scott Durham and Douglass Matthew Turnbull},
  journal={Investigative ophthalmology & visual science},
  volume={42 12},
PURPOSE To evaluate somatic mitochondrial (mt)DNA mutations in the macula during ageing. METHODS Ten 30-microm cryostat sections from the macula (foveal and perifoveal regions) and peripheral retina of 14 donors (aged 14-94 years) were cut for cytochrome c oxidase cytochemistry. The photoreceptor layer was microdissected and DNA extracted for 4977-bp mtDNA (mtDNA(4977)) quantification using PCR. Dual cytochemistry for cytochrome c oxidase and succinate dehydrogenase allowed the detection of… CONTINUE READING
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