Mitochondrial abnormalities: A primary basis for oxidative damage in Alzheimer's disease

@inproceedings{Smith1999MitochondrialAA,
  title={Mitochondrial abnormalities: A primary basis for oxidative damage in Alzheimer's disease},
  author={Mark Smith and Keisuke Hirai and Akihiko Nunomura and George Perry},
  year={1999}
}
The most striking feature of Alzheimer's disease (AD) is the number of abnormalities affecting essentially every aspect of brain homeostasis. Recent work suggests that increased oxidative stress that damages lipids, proteins, and nucleic acids and results in the accumulation of redox-active metals may be responsible for the diversity of systems involved. Interestingly, all of the genetic factors, β-protein precursor, presenilins, and apolipoprotein E, have been linked to reactive oxygen species… CONTINUE READING